Did you know the open-source anti-virus ClamAV supports YARA rules? What benefits can this bring to us? One of the important features ClamAV has is the file decomposition capability. Say that the file you want to analyze resides in an archive, or is a packed executable, then ClamAV will unarchive/unpack the file, and run the YARA engine on it.
A lot of people actually don't know this. But NVISIO wrote a great article on it and is definitely worth the read if you are interested in doing some hunting with Yara content with ClamAV.